Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropathology

Background. The role of recently discovered neurospecific peptides in the pathogenesis acute and progressive neurologic disorders, their neuroprotective features, possibilities to use them as markers for course prognosis certain diseases have been actively studied recent decades. However, are almost not chronic residual diseases. In our study we measured levels some other achieve understanding general neurophysiological trends congenital acquired non-progressive brain pathology with reference selection relevant groups — objects. Objective. aim is patterns peptides, neurotransmitters neuroreceptor distribution serum children various pathogenetic variants neuropathology. Methods. included from 3 16 years old different pathologies. sample was divided into by type: no sensory neurological deficit due mutation genes expressed brain, early multifactorial nature, mild severe organic disorders central nervous system (CNS) stage without baseline deficit, functional CNS defect deficit. following laboratory data (neurophysiological components) studied: nerve growth factor, brain-derived neurotropic neurotrophin-3, neurotrophin-4, neuregulin-1-beta-1, beta-secretase, sirtuin-1, synaptophysin, neuronal nitric oxide synthase, anti-NR2 glutamate receptor antibodies. parameters cognitive activity, sense vision, smell, acoustic were also evaluated. Results. 274 participants. Neuropeptides shown a variable degree range group spectrum differences normal levels. most examined NO-synthase, well both neurotrophins, marker. All visual deficits associated increased NO-synthase (p < 0.001). Neuroplasticity (beta-secretase, neurotrophin-3 4) activated all pathological conditions. Nerve factor specifically lesions (mild impairments), while neuregulin genetically determined deficits. There specific activation neuropeptides level tended decrease cases lesions. Conclusion. results suggest that types impairment physiological non-organic mainly synaptic activity. General neuroplasticity processes but more specific. well-studied lesions, did activate adequately probably limited resources.